Reflecting a decade's worth of changes, this second edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models used in toxicology and an overview of broad considerations of metabolism and its relevance. Chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory "course" along with guidance to the literature for more detailed understanding.