Fundamental Immunology > Immunology

An authoritative presentation of the basic elements of the immune system and of the means through which the mechanisms of immunity act in a wide range of clinical conditions, including protection against infectious agents, rejection of tumors, transplantation of tissues and organs, autoimmune and other immunopathologic conditions, and allergy. Reflecting progress in virtually every aspect of the field, this edition gives explicit chapter status to many new subjects, includes contributions from many new authors, and, with few exceptions, is entirely rewritten

Acknowledgments
Preface
Introduction
1 The Immune System: An Introduction 1
2 The History of Immunology 19
Immunoglobulins and B Lymphocytes
3 Immunoglobulins: Structure and Function 37
4 Antigen-Antibody Interactions and Monoclonal Antibodies 75
5 Immunoglobulins: Molecular Genetics 111
6 B-Lymphocyte Development and Biology 183
7 B-Lymphocyte Activation 225
T Lymphocytes
8 The Major Histocompatibility Complex 263
9 Antigen Processing and Presentation 287
10 T-Cell Antigen Receptors 341
11 T-Lymphocyte Differentiation and Biology 367
12 T-Lymphocyte Activation 411
13 Accessory Molecules 449
Organization of the Immune System
14 Lymphoid Tissues and Organs 479
15 Macrophages and the Immune Response 533
16 Dendritic Cells 547
17 Natural Killer Cells 575
18 Origin and Evolution of the Vertebrate Immune System 605
Regulation of the Immune Response
19 Immunogenicity and Antigen Structure 651
20 Immunological Tolerance 701
21 Type I Cytokines and Interferons and Their Receptors 741
22 Proinflammatory Cytokines: TNF and IL-1 Families, Chemokines, TGF-[beta], and Others 775
23 Apoptosis 813
24 Immunoglobulin Class Switching 831
25 Affinity Maturation 863
26 Differentiation of Effector Phenotypes of CD4[superscript +] and CD8[superscript +] T Cells 879
27 The Mucosal Immune System 909
28 Aging and Immune Function 947
Effector Mechanisms of Immunity
29 Complement 967
30 Phagocytosis 997
31 Cytotoxic T Lymphocytes 1021
32 Inflammation 1051
Mechanistic Basis of Immunology
33 Systemic Autoimmunity 1067
34 Organ-specific Autoimmunity 1089
35 Allergy 1127
36 Transplantation Immunology 1175
37 Tumor Immunology 1237
38 Immune Regulation in Parasitic Infection and Disease 1271
39 Immunity to Viruses 1295
40 Immunity to Intracellular Bacteria 1335
41 Immunity to Extracellular Bacteria 1373
42 Vaccines 1387
43 Primary Immunodeficiency Diseases 1427
44 The Immunopathogenesis of HIV Infection 1455
45 Immunotherapy 1511
Index 1535

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