Lupus: Molecular and Cellular Pathogenesis > Basic Research

Summarizes recent research on the molecular and cellular origins of lupus, reviewing mechanisms underlying abnormal immunity and introducing the powerful new concept that a disorder of multiple genes underlies the abnormal immune response in lupus. This pathophysiology is shown to involve a wide variety of cell types and an overproduction of pathologic autoantibodies, producing a destructive inflammatory response. Explains new concepts of signal transduction, drug-induced lupus, adhesion molecules, and nitric oxide, and reviews T- and B-cell function abnormalities. Of interest to immunologists, rheumatologists, pathologists, and dermatologists

1 Lupus: The Clinical Entity 1
2 The Vascular Endothelium: A New Actor in The Pathogenesis of Vascular Injury in Systemic Lupus Erythematosus 13
3 Nitric Oxide in Systemic Lupus Erythematosus: Implications for Immunity and Inflammation 21
4 Molecular Mimicry, Altered Apoptosis, and Immunomodulation as Mechanisms of Viral Pathogenesis in Systemic Lupus Erythematosus 43
5 Clustering and Proteolytic Cleavage of Autoantigens in Surface Blebs of Apoptotic Cells: Implications for Pathogenesis of SLE 65
6 Immune Effects of Bacterial DNA and Their Possible Role in the Pathogenesis of Lupus 79
7 Genetics of Systemic Lupus Erythematosus 101
8 Genetic Insights into Murine Lupus 124
9 Murine Graft-vs-Host Disease: Relevance to Human Lupus Immunopathogenesis and Therapy 140
10 Lessons From Knockout and Transgenic Lupus-Prone Mice 152
11 B Cells in Systemic Lupus Erythematosus 167
12 Mechanisms of the Pathogenic Autoimmune Response in Lupus: From Mouse Models to Human Disease 181
13 T-Cell Autoimmunity in Lupus: Ignorance, Anergy, and Activation 202
14 T-, B-, and Natural Killer Cell Dysfunction in Murine Systemic Lupus Erythematosis Models 220
15 Mechanisms of T-Helper Cell Activation and Function in Systemic Lupus Erythematosus 231
16 A Genetic Mechanism Underlying Deficient Type I Protein Kinase A Activity in Systemic Lupus Erythematosus T Lymphocytes 257
17 Impaired DNA Methylation in Lupus T Cells 278
18 Impaired Non-Antigen-Specific T-Cell Cytolytic Activity in SLE 299
19 Natural Killer Cells and CD8[superscript +] T Cells in the Downregulation of Antibody Production in Healthy Subjects and SLE: A Role for Transforming Growth Factor-[beta] and Interleukin-2 312
20 Cytokines in the Immunopathogenesis of Lupus 321
21 Cytokine Gene Expression in Human Systemic Lupus Erythematosus 341
22 Balance Between Type 1 and Type 2 Cytokine-Secreting Cells: Impact on Disease Activity in Systemic Lupus Erythematosus 361
23 Autoantibodies as a Source of Peptides That Regulate Autoantibody Production 371
24 Autoantibodies to Intracellular Antigens in Systemic Lupus Erythematosus Patients That Bind and Penetrate Cells 389
25 Pathogenesis of Autoantibody Production and Glomerulonephritis in Pristane-Treated Mice: An Inducible Model of SLE 399
26 Anti-DNA Antibodies: Markers of the Pathogenesis of Systemic Lupus Erythematosus 417
27 The Anti-DNA Response in Lupus: Structure, Initiation, and Pathogenesis 429
28 Glomerular Binding Antibodies in Systemic Lupus Erythematosus 448
29 The Antiphospholipid Syndrome: Mechanisms of Autoantibody-Mediated Thrombosis 471
30 Autoimmune-Associated Congenital Heart Block: Bringing Bedside Challenges to the Bench 492
31 Role of Calreticulin Autoimmunity in the Pathogenesis of Photosensitive Cutaneous Lupus Erythematosus 514
32 Complement System and Systemic Lupus Erythematosus 529
33 Type One Complement Receptor and Human SLE 541
34 Fc[gamma] Receptor Polymorphisms: Insights into Pathogenesis 557
35 Immune Complexes and Autoantibodies to Clq 574
36 Lipids and Lupus: The Fats of the Matter 599
37 Immunosuppressive Agents: Biologic Effects In Vivo and In Vitro 612
38 Treatment of Systemic Lupus Erythematosus by Selective Inhibition of T-Cell Function 642
39 Targeting Costimulatory and Other Signaling Molecules in Murine Lupus 656
40 Management of Murine Lupus by Correction of Fas and Fas Ligand-Induced Apoptosis: Therapeutic Rationale and Strategies 671
Index 695

등록된 상품문의

상품문의 쓰기 새 창 더보기

상품문의가 없습니다.