Disorders of Bone and Mineral Metabolism 2th > Basic Research

hardcover - 1090 pages, 566 ills.
This important volume is the most comprehensive reference ever published on the pathophysiology, clinical characteristics, diagnosis, and management of bone disorders and disturbances in mineral metabolism. More than 50 leading specialists in pertinent clinical and research areas--including endocrinology, orthopedics, nephrology, urology, physiology, pathology, biochemistry, and molecular biology--integrate fundamental scientific principles with cogent clinical observations. Their objective is to establish a systematic approach to the timely diagnosis and optimal management of these frequently complex disorders. The methodically organized and clearly written text is supplemented by extensive, current bibliographic references and complemented by more than 500 illustrations--including nearly 20 full-color illustrations of bone biopsy findings in the major metabolic skeletal disorders. Succinct but thorough introductory reviews of normal mineral metabolism and bone structure and biology lay the groundwork for the clinically oriented discussions that follow. The book then describes current laboratory and radiographic methods (including bone scanning) for diagnosis of clinical mineral disorders and offers definitive guidance on the indications for bone biopsy and the evaluation of biopsy specimens. The remainder of the book covers the entire spectrum of inherited and acquired derangements of serum mineral levels, disorders of stone formation, and bone disorders, including those related to cancer, endocrine disturbances, nutritional disorders, and renal, gastrointestinal and hepatic disease

I Normal Mineral Metabolism
1 Renal Handling of Calcium and Phosphorus 3
2 Physiology and Pathophysiology of Renal Magnesium Handling 34
3 Intestinal Absorption of Calcium, Magnesium, and Phosphorus 48
4 Parathyroid Hormone-Synthesis and Secretion 74
5 Target Tissue Actions, Metabolism, and Assay of Parathyroid Hormone 102
6 Parathyroid Hormone-related Protein 129
7 Vitamin D: Synthesis, Metabolism, and Clinical Measurement 157
II Bone Structure and Biology
8 Embryology, Anatomy, and Microstructure of Bone 177
9 The Cell and Molecular Biology of Bone Formation 199
10 Mechanisms of Biomineralization 227
11 Mechanisms and Regulation of Bone Resorption by Osteoclastic Cells 235
12 Biology, Chemistry, and Biochemistry of the Mammalian Growth Plate 255
13 Bone Remodeling 315
III Mineral Metabolism During the Human Life Cycle
14 Mineral Metabolism during Pregnancy and Lactation 347
15 Bone and Mineral Metabolism during Childhood 360
16 Integration of Calcium Metabolism in the Adult 381
IV Introduction to Clinical Mineral Disorders
17 Clinical and Laboratory Approach to the Patient with Disorders of Bone and Mineral Metabolism 399
18 Bone Mass Measurement 406
19 Radiologic Imaging of Metabolic Bone Disease 428
20 Clinical Use of Bone Biopsy 448
21 Physiologic and Pathogenetic Significance of Bone Histomorphometric Data 469
V Disorders of Serum Mineral Levels
22 Hypercalcemic States: Differential Diagnosis and Acute Management 489
23 Primary Hyperparathyroidism 516
24 Disorders of Serum Minerals Caused by Cancer 535
25 Hypercalcemia and Abnormal Vitamin D Metabolism 557
26 The Hypocalcemic States 568
27 Disorders of Phosphate and Magnesium Metabolism 589
VI Disorders of Stone Formation
28 Physical-Chemical Processes in Kidney Stone Formation 619
29 Mechanisms of Stone Description and Dissolution 629
30 Idiopathic Hypercalciuria 673
31 Hyperoxaluric States 698
32 Calcium Nephrolithiasis and Renal Tubular Acidosis 717
33 Inhibitors and Promoters of Calcium Oxalate Crystallization: Their Relationship to the Pathogenesis and Treatment of Nephrolithiasis 741
34 Noncalcium Urinary Calculi 776
VII Disorders of Bone
35 Primary Osteoporosis 805
36 Treatment of Osteoporosis 831
37 Secondary Forms of Osteoporosis 847
38 Bone Disease in Chronic Renal Failure and after Renal Transplantation 865
39 Bone Disease Resulting from Inherited Disorders of Renal Tubule Transport and Vitamin D Metabolism 898
40 Bone Disease Due to Nutritional, Gastrointestinal and Hepatic Disorders 918
41 Hereditary Metabolic and Dysplastic Skeletal Disorders 937
42 Paget's Disease of Bone 985
43 Primary Cystic and Neoplastic Diseases of Bone 1021
Subject Index

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