Cell Physiology Source Book > Cell Biology

This completely revised and updated source book provides comprehensive and authoritative coverage of cell physiology and membrane biophysics. Intended primarily as a text for advanced undergraduate and graduate students and as a reference for researchers, this multidisciplinary book includes several new chapters and is an invaluable aid to scientists interested in cell physiology, biophysics, cell biology, electrophysiology, and cell signaling.

Sect. I Biophysical Chemistry, Metabolism, Second Messengers, and Ultrastructure
1 Biophysical Chemistry of Physiological Solutions 3
App Thermodynamics of Membrane Transport 16
2 Physiological Structure and Function of Proteins 19
3 Structural Organization and Properties of Membrane Lipids 43
4 Cell Membranes and Model Membranes 65
5 Lipid Domains and Biological Membrane Function 81
6 Ultrastructure of Cells 95
7 Energy Production and Metabolism 119
8 Physiology of Mitochondria 139
9 Signal Transduction 153
10 Calcium as an Intracellular Second Messenger: Mediation by Calcium-Binding Proteins 167
11 Regulation of Cellular Functions by Extracellular Calcium 179
12 Cellular Responses to Hormones 191
Sect. II Membrane Potential, Transport Physiology, Pumps, and Exchangers
13 Diffusion and Permeability 209
App Exponential Time Course of Diffusion 217
14 Origin of Resting Membrane Potentials 219
Appendix 237
15 Gibbs-Donnan Equilibrium Potentials 243
16 Mechanisms of Carrier-Mediated Transport: Facilitated Diffusion, Cotransport, and Countertransport 249
17 Sodium Pump Function 261
18 Ca[superscript 2+] - ATPases 271
19 Na[superscript +]-Ca[superscript 2+] Exchange Currents 283
20 Intracellular Chloride Regulation 301
21 Osmosis and Regulation of Cell Volume 319
22 Intracellular pH Regulation 357
App Techniques for pH Measurement 373
23 Membrane Transport in Red Blood Cells 377
Sect. III Membrane Excitability and Ion Channels
24 Cable Properties and Propagation of Action Potentials 395
App. 1 Propagation in Cardiac Muscle and Smooth Muscles 407
App. 2 Derivation of the Cable Equation and the AC Length Constant 412
25 Electrogenesis of Membrane Excitability 417
26 Patch-Clamp Techniques and Analysis 441
27 Structure and Mechanism of Voltage-Gated Ion Channels 455
28 Biology of Neurons 479
29 Ion Channels in Nonexcitable Cells 485
30 Ion Channels in Sperm 509
31 Biology of Gap Junctions 523
32 Biophysics of the Nuclear Envelope 539
33 Regulation of Ion Channels by Phosphorylation 559
34 Direct Regulation of Ion Channels by G Proteins 573
35 Developmental Changes in Ion Channels 585
36 Regulation of Ion Channels by Membrane Proteins and Cytoskeleton 601
Sect. IV Ion Channels as Targets for Toxins, Drugs, and Genetic Diseases
37 Ion Channels as Targets for Toxins 625
38 Ion Channels as Targets for Drugs 643
39 Ion Channels as Targets for Disease 653
Sect. V Synaptic Transmission and Sensory Transduction
40 Ligand-Gated Ion Channels 675
41 Synaptic Transmission 689
42 Excitation-Secretion Coupling 705
43 Stimulus-Response Coupling in Metabolic Sensor Cells 725
44 Mechanosensitive Ion Channels in Eukaryotic Cells 745
45 Sensory Receptors and Mechanotransduction 761
46 Acoustic Transduction 775
App Self-Referencing Electrodes for the Measurement of Extracellular Potential and Chemical Gradients 792
47 Cyclic Nucleotide-Gated Ion Channels 795
48 Visual Transduction 807
49 Gustatory and Olfactory Sensory Transduction 815
App Infrared Sensory Organs 832
50 Electroreceptors and Magnetoreceptors 839
App The Biophysics of Electroreception in Ampullary Organs of Elasmobranch Fishes 857
Sect. VI Muscle and other Contractile Systems
51 Skeletal Muscle Action Potentials 865
52 Cardiac Action Potentials 887
53 Smooth Muscle Action Potentials and Electrical Profiles 899
54 Excitation-Contraction Coupling in Skeletal Muscle 911
55 Ca[superscript 2+] Release from Sarcoplasmic Reticulum in Muscle 927
56 Contraction of Muscles 941
57 Amoeboid Movement, Cilia, and Flagella 959
58 Centrin-Based Contraction and Bacterial Flagella 985
59 Effects of High Pressure on Cellular Processes 1003
60 Electrocytes of Electric Fish 1025
Sect. VII Protozoa and Bacteria
61 Physiological Adaptations of Protists 1041
62 Physiology of Prokaryotic Cells 1063
Sect. VIII Plant Cells, Photosynthesis, and Bioluminescence
63 Plant Cell Physiology 1079
64 Photosynthesis 1097
65 Bioluminescence 1115
Sect. IX Cell Division and Programmed Cell Death
66 Regulation of Cell Division in Higher Eukaryotes 1135
67 Cancer Cell Properties 1161
68 Apoptosis 1171
69 Effects of Ionizing Radiation of Cells 1185
70 Review of Electrically and Cable Properties 1205
Index 1221

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