Cardiac Remodeling: Mechanisms and Treatment > Cardiology

Containing more than 10 pages of color photographs, this guide
reviews the results of key clinical studies that demonstrate the role that progessive cardiac remodeling plays in the progression of heart failure
presents new and emerging therapies for the treatment of remodeling, including the use of stem cell and gene transfer therapies
provides broad coverage of the complex relationships between cardiac injury, the remodeling process, and the development of cardiac dysfunction
focuses on molecular and cellular mechanisms of action including alterations in gene expression, the role of apoptosis and myocyte regeneration, oxidative stress, and neurohormonal activation in cardiac remodeling
extensively analyzes clinical trials results that relate changes in remodeling to beneficial clinical outcomes such as a reduction in the progression of heart failure and improved survival rates
Exploring the causes, mechanisms, and pathophysiology of cardiac remodeling, this reference offers detailed descriptions of the various components of the remodeling process, as well as new therapeutic interventions and recent and future prospects for the treatment of cardiac remodeling.

Overview: What is Cardiac Remodeling?
Structural and Mechanical Aspects of Remodeling.
What Differentiates Physiological from Pathophysiologic Remodeling?
Myocyte Signaling During the Transition from Hypertrophy to Heart Failure.
Cardiac Myocyte Structural Remodeling.
Myocyte Loss and Regeneration During Cardiac Remodeling.
Role of the Interstitial Matrix in Maintaining Cardiac Function.
Changes in the Interstitial Matrix During Cardiac Remodeling.
Bioenergetic Abnormalities in the Remodeling Heart.
Experimental Animal Models of Remodeling.
The Use of Transgenic Animals to Study Cardiac Remodeling.
The Effects of Pressure and Volume Load on Cardiac Structure and Remodeling. The Role of the Renin-Angiotensin Aldosterone System in Cardiac Remodeling. Adrenergic Pathways that Result in Cardiac Remodeling.
Cytokines and Their Effects on Cardiac Remodeling.
Other Factors Related to Cardiac Remodeling. Functional Consequences of the Remodeling Process.
Epidemiology of Cardiac Remodeling.
Clinical Assessment of Remodeling. Inhibition of the Renin-Angiotensin Aldosterone System.
Effects of Adrenergic Blockade on Remodeling.
Other Medical Therapies for Treating Cardiac Remodeling. T
he Effects of Cardiac Revascularization on the Remodeling Process.
Valve Replacement and Repair. Cardiac Remodeling After LVAD Replacement. Cardiac Resynchronization Therapy.
Other Surgical or Device-Based Approaches to Treating Cardiac Remodeling. Gene Transfer Therapy in the Treatment of Cardiac Remodeling.
Future Strategies for Reversing the Remodeling Process

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