Joint Replacement And Bone Resorption: Pathology, Biomaterials And Clinical Practice > Basic Research

Written by eminent surgeons and scientists at the front-lines of orthopaedic surgery and research, this guide
explains key opportunities in genomics and proteomics which can be used to enhance the understanding of patient variables associated with the failure of joint replacements
summarizes the essential engineering principles of joint replacements such as properties of biomaterials, wear and its sequelae, corrosion, and the fixation of implants
provides critical assessment of the different causes of osteolysis around implants
describes innovations in materials commonly used in joint replacement components including metals, bone cement, and ultra high molecular weight polyethylene
offers an in-depth treatment of the different mechanisms associated with bone loss around joint replacements, with particular focus on cellular and molecular mechanisms of action
supplies a thorough review of the causes and possible solutions to bone loss
describes the potential for tissue engineering alternatives for cartilage restoration
summarizes the importance of using laboratory models for the investigation of bone loss and the development of therapeutic strategies
This first guide devoted to this burgeoning topic, this authoritative reference presents the current understanding of the phenomenon of aseptic loosening of total joint replacements from the molecular and cellular mechanisms of periprosthetic bone loss to the clinical presentation and management strategies-reviewing the properties of ceramic, metal, and polymer materials used in the replacement of joints, as well as current research on bone remodeling, wear resistance, the long-term care of implants, and emerging developments in gene therapy and tissue engineering.

Table of Contents
Clinical Practice. Historical Perspective. Fixation of Implants.
THR: Incidence of Bone Loss and Clinical Presentation.
TKR: Incidence of Bone Loss and Clinical Presentation.
Histopathology of Periprosthetic Tissues.
Biomaterials Wear Debris.
Basic Science.
Properties of Materials Used in Joint Replacements.
Wear in Joint Replacements. Human Motion and its Relevance to Wear.
Corrosion.
Inflammation and the Role of Macrophages.
Cytokines and Mediators in Physiological and Pathologic Bone Resorption. Mechanisms of Peri-Implant Bone Loss.
Wear Debris Induced Osteolysis. Role of Immune-Response in Implant Loosening. Stress-Induced Bone Remodeling.
Pressure and Motion Induced Factors in Implant Loosening.
Role of Endotoxin in Implant Loosening.
Signal Transduction and Gene Regulation in Cell-Material Interactions.
In-Vitro and In-Vivo Models to Study Osteolysis.
Solutions and Treatments.
Surgical Techniques: Modern Cementing Techniques.
Treating Hip and Pelvic Osteolysis.
Managing Knee Osteolysis.
Advances in Metals.
Advances in Polyethylene.
Improving UHMWPE Using Electron Beam Irradiation.
Alternate Bearing Materials: Metal-on-Metal.
Alternate Bearing Materials: Ceramic-on-Ceramic.
Future Perspectives.
Tissue Engineering Alternatives to Joint Replacement.
Enhancing Bone Ingrowth.
Gene Therapy for Osteolysis.
Pharmaceutical Treatment of Lysis.
Genomics: The Promise for Orthopaedics

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