Rheumatoid Arthritis,2/e > Rheumatology

This book describes the latest advances in our understanding of this common, crippling disease and relates this knowledge to the application of a more rational therapeutic approach to its management. The book covers the scientific basis of the pathogenesis of rheumatoid arthritis and the rationale for the treatment, both drug and non-drug, of the disease.

Preface
Section 1
Etiology
1. Genetics of rheumatoid arthritis, PK Gregersen, RM Plenge, PS Gulko
2. Epidemiology and determinants of susceptibility, Graciela S Alarcon, Jaime Calvo-Alen
3. Microbes in the pathogenesis of rheumatoid arthritis, Paavo Toivanen
4. Experimental models for rheumatoid arthritis, Rikard Holmdahl
Section 2
Mechanisms of inflammation
5. The role of macrophages in rheumatoid arthitis, Raimund Kinne, Bruno Stuhmuller, Ernesta Palombo-Kinne & Gerd R Burmetser
6. The role of T lymphocytes in rheumatoid arthritis, David A Fox
7. The role of neutrophils in the pathogenesis of rheumatoid arthritis, Robert P Kimberly, Jeffrey C Edberg & W Winn Chatham
8. The role of fibroblast-like synoviocytes in rheumatoid arthritis, Ulf Muller-Ladner & Steffen Gay
9. The roles of B cells in rheumatoid arthritis, Greg Silverman
10. Innate immunity and immune complexes in rheumatoid arthritis, Peter Nigrovic & David Lees
11. Angiogenesis and cell trafficking, Christopher Buckley, Andrew Filer & Costantino Pitzalis
12. Cytokine networks, William Arend & Cem Gabay
13. Autoantibodies in rheumatoid arthritis, Gunter Steiner & Josef S Smolen
14. Mechanisms of fibroblast-mediated joint destruction, Thomas Pap, Renate E Gay & Steffen Gay
15. Pain mechanisms in rheumatoid arthritis, Bruce L Kidd
16. The stress system and the hypothalamic-pituitary adrenal (HPA) axis in rheumatoid arthritis, Georg P Chrousos & Gregory A Kaltasa
Section 3
Clinical Aspects
17. Examination of the synovium and synovial fluid, Paul-Peter Tak
18. Clinical aspects of rheumatoid arthritis, Nathan J Zvaifler
19.Imaging in rheumatoid arthritis, Mikkel Ostergaard, Marcin Szkudlarek & Bo Jannik Ejbjerg
20. Susceptibility, prognosis & mortality, Marjatta Leirisalo-Repo
21. Biomarkers for cartilage and bone in rheumatoid arthritis, Tore Saxne, Bengt Mansson & Dick Heinegarard
Section 4
Drug Therapy
22. NSAIDS and analgesics, Garry Graham, Richard O'Day, Lynette M March, Kieran F Scott & Kenneth M Williams
23. Systemic and intra-articular glucorticoids in rheumatoid arthritis, Johannes WJ Bijlsma, Frank Buttgereit & Johannes WG Jacobs
24. Methotrexate and Leflunomide, Rolf Rau
25. Gold, antimalarials, sulfasalazine, and other DMARDS, Piet LCM van Riel & Eric-Jan Kroot
26. Combination therapy with synthetic DMARDs in the treatment of rheumatoid arthritis, Antonios O Aliprantis & Michael Weinblatt
27. Biologics in the treatment of rheumatoid arthritis, Zuhre Tutuncu & Arthur Kavanaugh
Section 5
Non-Drug Therapy
28. The impact of physiotherapy, Ulrich Mortiz
29. Patient Education, Ylva Lindroth
30. Occupation therapy and assistive products and technology, Ulla Nordenskiold
31. Psychological and social aspects, Tore Kristian Kvien & Liv Marit Smedstad
32. Pain management, Wolfgang Haman
33. Health econoics, Leigh F Callahan
Section 6
Surgical Therapy
34. Large joints and feet, Urban Rydholm
35. The hand, Christer Sollerman
36. The cervical spine, ATH Casey & Alan Crockard
Section 7
Frontiers of Therapy
37. Design of trials involving clinical endpoints, Louise Pollard, Gabrielle Kingsley & David Scott
38. Clinical trials with imaging and biomark endpoints, Jane Freeston & Paul Emery
39. New biologics: cytokines, Larry W Moreland & Jeffrey Curtis
40. New biologics: T and B cell modulators, Ernest Choy
41. Inhibibition of proteolytic activity involved in cartilage breakdown, Tim E Cawston & David A Young
42. Signal transduction in rheumatic diseases, Di Chen & Edward Schwarz
43. Mesenchymal stem cells in arthritis, Frank Luyten

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