Pigmentary System, 2/e > Dermatology

The most comprehensive and integrated book on pigmentation
The Pigmentary System gathers into one convenient, all-inclusive volume a wealth of information about the science of pigmentation and all the common and rare clinical disorders that affect skin color. The two parts, physiology (science) and pathophysiology (clinical disorders), are complementary and annotated so that those reading one part can easily refer to relevant sections in the other. For the clinician interested in common or rare pigment disorders or the principles of teaching about such disorders, this book provides an immediate and complete resource on the biologic bases for these disorders. For the scientist studying the biology of melanocyte function, the book provides a list of disorders that are related to basic biological functions of melanocytes.
New features of the second edition include:
Completely new section on the basic science of pigmentation - explaining the integration of melanocyte functions with other epidermal cells and with various organ systems like the immune system
New chapters on pigmentary disorders related to intestinal diseases, the malignant melanocyte, benign proliferations of melanocytes (nevi) and phototherapy with narrow band UV
All clinical chapters include the latest genetic findings and advances in therapy
More than 400 color images of virtually all clinical disorders
The book is ideal for all dermatologists and especially those interested in disorders of pigmentation. It is of particular use for pediatric dermatologists and medical geneticists caring for patients with congenital and genetic pigmentary disorders. This authoritative volume will fill the gap for dermatology training programs that do not have local experts on pigmentation. Basic and cosmetic scientists studying pigmentation and melanocytes will find the science and clinical correlations very useful in showing human significance and relevance to the results of their studies.

Part I: The Physiology of the Pigmentary System
Section 1: Historical and Comparative Perspectives of
the Pigmentary System
1 A History of the Science of Pigmentation
2 Comparative Anatomy and Physiology of Pigment Cellsin Nonmammalian Tissues
Section 2: The Science of Pigmentation
3 General Biology of Mammalian Pigmentation
4 Extracutaneous Melanocytes
5 Regulation of Melanoblast Migration and Differentiation
6 Melanoblast Development and Associated Disorders
7 Biogenesis of Melanosomes
8 Melanosome Trafficking and Transfer
9 Melanosome Processing in Keratinocytes
10 The Regulation of Melanin Formation
11 The Tyrosinase Gene Family
12 Molecular Regulation of Melanin Formation: Melanosome Transporter Proteins
13 Transcriptional Regulation of Melanocyte Function
14 Enzymology of Melanin Formation
15 Chemistry of Melanins
16 The Physical Properties of Melanins
17 Photobiology of Melanins
18 Toxicological Aspects of Melanin and Melanogenesis
19 Regulation of Pigment Type Switching by Agouti, Melanocortin Signaling, Attractin, and Mahoganoid
20 Human Pigmentation: Its Regulation by Ultraviolet Light and by Endocrine, Paracrine, and Autocrine Factors
21 Paracrine Interactions of Melanocytes in Pigmentary Disorders
22 Growth Factor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of Melanocytes
23 Aging and Senescence of Melanocytes
24 The Genetics of Melanoma
25 The Transformed Phenotype of Melanocytes
Part II: The Pathophysiology of Pigmentary Disorders
Section 3: An Overview of Human Skin Color and its Disorders
26 A More Precise Lexicon for Pigmentation, Pigmentary Disorders, and "Chromatic" Abnormalities
27 The Normal Color of Human Skin
28 Mechanisms that Cause Abnormal Skin Color
Section 4: Disorders of Hypopigmentation, Depigmentation and Hypochromia
29 Genetic Hypomelanoses: Disorders Characterized by Congenital White Spotting - Piebaldism, Waardenburg Syndrome, and Related Genetic Disorders of Melanocyte Development - Clinical Aspects
30 Genetic Hypomelanoses: Acquired Depigmentation
Rozycki Syndrome
Vitiligo Vulgaris
31 Genetic Hypomelanoses: Generalized
Hypopigmentation
Oculocutaneous Albinism
Albinoid Disorders
Ataxia Telangiectasia
Hallerman-Streiff Syndrome
Histidinemia
Homocystinuria
Oculocerebral Syndrome with Hypopigmentation
Tietz Syndrome
Kappa-Chain Deficiency
Menkes' Kinky Hair Syndrome
Phenylketonuria
32 Genetic Hypomelanoses: Localized Hypopigmentation
"Hypomelanosis of Ito" and Mosaicism
Focal Dermal Hypoplasia
Hypomelanosis with Punctate Keratosis of the Palms and Soles
Darier-White Disease (Keratosis Follicularis;124200)
Nevus Depigmentosus
Tuberous Sclerosis Complex
33 Genetic Hypomelanoses: Disorders Characterized by Hypopigmentation of Hair
Bird-Headed Dwarfism (Seckel Syndrome)
Down Syndrome
Fisch Syndrome
Premature Canities
Mandibulofacial Dysostosis (Treacher Collins Syndrome)
Myotonic Dystrophy
PHC Syndrome (Böök Syndrome)
Pierre Robin Syndrome
Prolidase Deficiency
34 Metabolic, Nutritional, and Endocrine Disorders Metabolic and Nutritional Hypomelanoses
Hypomelanosis Associated with Endocrine Disorders
35 Chemical, Pharmacologic, and Physical Agents Causing Hypomelanoses Chemical and Pharmacologic Agents Causing Hypomelanoses
Physical Agents Causing Hypomelanoses
36 Infectious Hypomelanoses
37 Inflammatory Hypomelanoses
38 Hypomelanoses Associated with Melanocytic Neoplasia
39 Miscellaneous Hypomelanoses: Depigmentation
Alezzandrini Syndrome
Idiopathic Guttate Hypomelanosis
Leukoderma Punctata
Lichen Sclerosus et Atrophicus
Vagabond Leukomelanoderma
Vogt-Koyanagi-Harada Syndrome
Westerhof Syndrome
Hereditary Sclerosing Poikiloderma
Mendes Da Costa Disease
Naegeli-Franceschetti-Jadassohn Syndrome
Reticulated Acropigmentation of Dohi (Dyschromatosis Symmetrica Hereditaria)
Reticulate Acropigmentation of Kitamura
Rothmund-Thomson Syndrome
40 Miscellaneous Hypomelanoses: Hypopigmentation
Disseminated Hypopigmented Keratoses
Hypermelanocytic Punctata et Guttata Hypomelanosis
Progressive Macular Hypomelanosis
Sarcoidosis
41 Miscellaneous Hypomelanoses: Extracutaneous Loss of Pigmentation
Alopecia Areata
Heterochromia Irides
Senile Canities
Sudden Whitening of Hair
42 Hypochromia without Hypomelanosis
Section 5: Disorders of Hyperpigmentation and Hyperchromia
43 Genetic Epidermal Syndromes: Disorders Characterized
by Generalized Hyperpigmentation Adrenoleukodystrophy
Familial Progressive Hyperpigmentation
Fanconi Anemia
Gaucher Disease
44 Genetic Epidermal Syndromes: Disorders Characterized by Reticulated Hyperpigmentation
Berlin Syndrome
Cantu Syndrome
Kindler Syndrome
Dermatopathia Pigmentosa Reticularis
Dyschromatosis Universalis Hereditaria
Epidermolysis Bullosa with Mottled Pigmentation
Familial Mandibuloacral Dysplasia
Hereditary Acrokeratotic Poikiloderma
Erythema Dyschromicum Perstans
Erythromelanosis Follicularis Faciei et Colli
Erythrose Péribuccale Pigmentaire of Brocq
Extracutaneous Neuroendocrine Melanoderma
Felty Syndrome and Rheumatoid Arthritis
Hyperpigmentation Associated with Human Immunodeficiency Virus (HIV) Infection
Melanoacanthoma
Phytophotodermatitis
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes: POEMS Syndrome
Urticaria Pigmentosum and Mastocytosis
Poikiloderma of Civatte
Riehl's Melanosis
Atrophoderma of Pasini et Pierini
Hyperpigmentation Associated with Scleromyxedema and Gammopathy
Ichthyosis Nigricans, Keratoses, and Epidermal Hyperplasia
Morphea and Scleroderma
Pigmentary Changes Associated with Addison Disease
Pigmentary Changes Associated with Cutaneous Lymphomas
45 Genetic Epidermal Syndromes with Café-au-lait Macules
Familial Multiple Café-au-lait Spots
Neurofibromatosis
Neurofibromatosis 1 with Noonan Syndrome
McCune-Albright Syndrome
Segmental Neurofibromatosis
Silver-Russell Syndrome
Watson Syndrome
46 Genetic Epidermal Pigmentation with Lentigines
Lentigo Simplex
Lentigo Senilis et Actinicus
Centrofacial Lentiginosis
LEOPARD Syndrome
Carney Complex
Other Lentiginoses
47 Genetic Epidermal Syndromes: Localized Hyperpigmentation
Anonychia with Flexural Pigmentation
Incontinentia Pigmenti
Periorbital Hyperpigmentation
48 Genetic Epidermal Syndromes: Disorders of Aging
Acrogeria
Metageria
Progeria
Xeroderma Pigmentosum
Werner Syndrome
49 Congenital Epidermal Hypermelanoses
Dyskeratosis Congenita
Ectodermal Dysplasias
Transient Neonatal Pustular Melanosis
Universal Acquired Melanosis
50 Acquired Epidermal Hypermelanoses
Acanthosis Nigricans
Acromelanosis Progressiva
Becker Nevus
Café-au-lait Spots
Carcinoid Syndrome
Confluent and Reticulated Papillomatosis
Cutaneous Amyloidosis
Dermatosis Papulosa Nigra
Ephelides (Freckles)
Erythema ab Igne
Pellagra
Peutz-Jeghers Syndrome
51 Hypermelanosis Associated with Gastrointestinal Disorders
Porphyria Cutanea Tarda
Cronkhite-Canada Syndrome
Hemochromatosis and Hemosiderosis
Primary Biliary Cirrhosis
Inflammatory Bowel Disease and Pigmentation
Pigmentary Demarcation Lines
Dowling-Degos Disease
52 Acquired and Congenital Dermal Hypermelanosis
Sacral Spot of Infancy
Nevus of Ota
Nevus of Ito
Phakomatosis Pigmentovascularis
Other Congenital Dermal Melanocytosis
Acquired Dermal Melanocytosis
Carleton-Biggs Syndrome
Acquired Bilateral Nevus of Ota-like Macules
(ABNOM)
Blue Macules Associated with Progressive Systemic
Sclerosis
53 Mixed Epidermal and Dermal Hypermelanoses and
Hyperchromias
Melasma
Melanosis from Melanoma
54 Drug-induced or -related Pigmentation
Section 6: Disorders of Pigmentation of the Nails and
Mucous Membranes
55 The Melanocyte System of the Nail and its Disorders,
56 Pigmentary Abnormalities and Discolorations of then Mucous Membranes
Section 7: Benign Neoplasms of Melanocytes
57 Common Benign Neoplasms of Melanocytes
Pigmented Spindle Cell Nevi
Speckled Lentiginous Nevus (Nevus Spilus)
Melanocytic (Nevocellular) Nevi and Their Biology
58 Rare Benign Neoplasms of Melanocytes
Nevus Aversion Phenomenon
Melanotic Neuroectodermal Tumor of Infancy
Pilar Neurocristic Hamartoma
Section 8: Treatment of Pigmentary Disorders
59 Topical Treatment of Pigmentary Disorders
60 Chemophototherapy of Pigmentary Disorders
61 UVB Therapy for Pigmentary Disorders
62 Sunscreens and Cosmetics
63 Surgical Treatments of Pigmentary Disorders
64 Laser Treatment of Pigmentary Disorders
Index
Plate section

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