Models of Seizures & Epilepsy > Neurology

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.
· The first comprehensive description of animal models of epilepsy since the early 1970s
· Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer
· Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research
· World expert opinions on the clinical relevance of each model

1 What should be modeled? 1
2 Single nerve cells acutely dissociated from animal and human brains for studies of epilepsy 15
3 Cell culture models for studying epilepsy 23
4 An overview of In Vitro seizure models in acute and organotypic slices 35
5 The use of brain slice cultures for the study of epilepsy 45
6 Hippocampal slices : designing and interpreting studies in epilepsy research 59
7 Thalamic, thalamocortical and corticocortical models of epilepsy with an emphasis on absence seizures 73
8 Studying epilepsy in the human brain In Vitro 89
9 In Vitro isolated guinea pig brain 103
10 Pharmacologic models of generalized absence seizures in rodents 111
11 Models of chemically-induced acute seizures 127
12 Electrical stimulation-induced models of seizures 153
13 Alcohol withdrawl seizures 161
14 Alumina gel injection models of epilepsy in monkeys 179
15 Modeling epilepsy and seizures in developing zebrafish larvae 189
16 Transgenic and gene replacement models of epilepsy : targeting ion channel and neurotransmission pathways in mice 199
17 Spontaneous epileptic mutations in the mouse 223
18 Genetic models of absence epilepsy in the rat 233
19 Models with spontaneous seizures and developmental disruption of genetic etiology 249
20 Mammalian models of genetic epilepsy characterized by sensory-evoked seizures and generalized seizure susceptibility 261
21 Inherited epilepsy in Mongolian gerbils 273
22 The cortical freeze lesion model 295
23 MAM and other "lesion" models of developmental epilepsy 305
24 In utero irradiation as a model of cortical dysplasia 315
25 Modeling hypoxia-induced seizures and hypoxic encephalopathy in the neonatal period 323
26 Complex febrile seizures - an experimental model in immature rodents 333
27 Repetitive seizures in the immature brain 341
28 The kindling phenomenon 351
29 Kindling kittens and cats 365
30 Electrical kindling in developing rats 371
31 Chemical kindling 379
32 Kindling, spontaneous seizures, and the consequences of epilepsy : more than a model 395
33 Tetanus toxin model of focal epilepsy 407
34 Kainate-induced status epilepticus : a chronic model of acquired epilepsy 415
35 The Pilocarpine model of seizures 433
36 Status epilepticus : electrical stimulation models
37 Posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats 465
38 Chronic partial cortical isolation 477
39 Head trauma : hemorrhage-iron deposition 495
40 Stroke 501
41 Models available for infection-induced seizures 521
42 Brain tumour and epilepsy : a new neurophysiologic and neuropathologic Ex Vivo In Vitro model 527
43 An animal model of Rasmussen's encephalitis 535
44 Therapeutic assays for the identification and characterization of antiepileptic and antiepileptogenic drugs 539
45 Animal models of drug-refractory epilepsy 551
46 Monitoring for seizures in rodents 569
47 Imaging approaches in small animal models 583
48 Behavioral characterization of seizures in rats 601
49 Behavioral and cognitive testing procedures in animal models of epilepsy 613
50 Morphologic approaches to the characterization of epilepsy models 629
51 Animal model development based on the human epilepsies : which causes and syndromes should be modeled? 653
52 What good are animal models? 659

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