Neurobiology of Mental Illness,3/e > Psychiatry

Hardcover - 1504pages, 3/e
This is a new edition of the first comprehensive text to show how the advances in molecular and cellular biology and in the basic neurosciences have brought the revolution in molecular medicine to the field of psychiatry.
The book begins with a review of basic neuroscience and methods for studying neurobiology in human patients then proceeds to discussions of all major psychiatric syndromes with respect to knowledge of their etiology, pathophysiology, and treatment. Emphasis is placed on synthesizing information across numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, and behavior, and in translating information from the basic laboratory to the clinical laboratory and finally to clinical treatment.
Editors Dennis Charney and Eric Nestle, along with their six section editors and over 150 contributors, have revised and updated all 80 chapters from the previous edition and have added new chapters on topics relating to, for example, genetics, experimental therapeutics, and late-life mood disorders. Both a textbook and a reference book, Neurobiology of Mental Illness is intended for psychiatrists, neuroscientists, and their students of trainees.

Pt. I Introduction to Basic Neuroscience
Introduction
1 Overview of Brain Development 3
2 Neurochemical Systems in the Central Nervous System 12
3 Using Basic Electrophysiology to Understand the Neurobiology of Mental Illness 29
4 Principles of Signal Transduction 41
5 Mechanisms of Neural Plasticity 66
6 Principles of Molecular Biology 76
7 Functional Genomics and Models of Mental Illness 87
Pt. II Methods of Clinical Neurobiological Research
Introduction
8 Contributions of Epidemiology to the Neurobiology of Mental Illness 103
9 Basic Methods for Clinical Molecular Genetics of Psychiatric Illness 112
10 Methods of Affective Clinical Psychophysiology 127
11 Clinical Neurochemistry 141
12 Clinical Neuroendocrinology 155
13 Neuroimmunology 171
14 Cognitive Neuroscience: Bridging Thinking and Feeling to the Brain, and Its Implications for Psychiatry 180
15 Neuroimaging Methodologies: Utilizing Radiotracers or Nuclear Magnetic Resonance 190
16 Methods of Postmortem Investigation of Human Brain 210
17 Drug Discovery and Development Methods for Mental Illness 221
Pt. III Psychoses
Introduction
18 Diagnostic Classification of the Psychoses: Historical Context and Implications for Neurobiology 237
19 Molecular Genetics of Schizophrenia 247
20 Animal Models of the Psychoses 263
21 Pharmacological Models of Psychoses 287
22 The Neurobiology of Schizophrenia 299
23 Functional Brain Imaging Studies in Schizophrenia 311
24 Psychophysiological and Information Processing Approaches to Schizophrenia 324
25 Principles of the Pharmacotherapy of Schizophrenia 339
Pt. IV Mood Disorders
Introduction
26 Diagnostic Classification of Mood Disorders: Historical Context and Implications for Neurobiology 357
27 Linkage and Association Studies of Bipolar Disorders 369
28 Animal Models of Mood Disorders 380
29 The Cellular Neurobiology of Bipolar Disorder 397
30 The Neurochemistry of Depressive Disorders: Preclinical Studies 421
31 The Neurochemistry of Depressive Disorders: Clinical Studies 440
32 Neuroimaging Studies of Mood Disorders 461
33 Principles of the Pharmacotherapy of Depression 491
34 Abnormalities of Brain Structure and Function in Mood Disorders Based Upon Postmortem Investigations 512
Pt. V Anxiety Disorders
Introduction
35 Diagnostic Classification of Anxiety Disorders: DSM-V and Beyond 525
36 Molecular Genetics of Anxiety 535
37 Animal Models of Anxiety Disorders 546
38 Structural and Functional Plasticity in the Hippocampal Formation: Stress, Adaptation, and Disease 558
39 Functional Neuroanatomy of Anxiety and Fear 584
40 The Neurobiology of Anxiety Disorders 605
41 The Neurobiology and Treatment of Obsessive-Compulsive Disorder 628
42 Neuroimaging Studies of Anxiety Disorders 639
43 Principles of Pharmacotherapy for the Anxiety Disorders 661
Pt. VI Substance Abuse Disorders
Introduction
44 Animal Models of Addiction 683
45 Cellular and Molecular Mechanisms of Drug Addiction 698
46 Genetic Epidemiology of Substance Use Disorders 710
47 Effects of Drugs of Abuse on Brain Development 720
48 Neuroimaging in Substance Abuse Research 740
49 Principles of the Pharmacotherapy of Substance Abuse Disorders 753
Pt. VII Dementia
Introduction
50 Diagnostic Classifications: Relationship to the Neurobiology of Dementia 771
51 The Molecular Biology of Alzheimer's Disease 783
52 Pharmacological and Transgenic Animal Models of Alzheimer's Disease 791
53 Functional Neuroanatomy of Learning and Memory 807
54 Neurochemical Systems Involved in Learning and Memory 813
55 Neuropathological and Neuroimaging Studies of the Hippocampus in Normal Aging and in Alzheimer's Disease 821
56 Abnormalities in Brain Structure on Postmortem Analysis of Dementia 836
57 Functional Brain Imaging Studies in Dementia 849
58 Principles of the Pharmacotherapy of Dementia 863
59 Cognitive Impairment in Demyelinating Disease 873
60 Dementia with Lewy Bodies
61 Dementia in Parkinson's Disease 896
Pt. VIII Psychiatric Disorders of Childhood Onset
Introduction
62 Developmental Neurobiology and the Childhood Onset of Psychiatric Disorders 921
63 Molecular Genetics of Childhood- and Adolescent-Onset Psychiatric Disorders 930
64 Neurobiology of Mental Retardation 944
65 The Neurobiology of Autism and the Pervasive Developmental Disorders 954
66 Tourette's Syndrome and Tic-Related Disorders in Children 968
67 Neurobiology of Attention Deficit Hyperactivity Disorder 979
68 The Neurobiology of Childhood Psychotic Disorders 1000
69 Neurobiology of Early-Onset Mood Disorders 1007
70 Childhood Anxiety Disorders: A Cognitive Neurobiological Perspective 1022
Pt. IX Special Topic Areas
71 Neuropsychiatry: The Border Between Neurology and Psychiatry 1049
72 The Neurobiology of Personality and Personality Disorders 1062
73 The Neurobiology of Aggression 1076
74 Sexual Dysfunction and Pharmacological Treatments: Biological Interactions 1086
75 The Neurobiology of Social Attachment 1101
76 The Neurobiology of Eating Disorders 1112
77 The Neurobiology of Menstrual Cycle-Related Mood Disorders 1129
78 The Neurobiology of Circadian Rhythms 1140
79 The Neurobiology of Sleep in Relation to Mental Illness 1160
80 Depression, Cardiovascular Disease, and Cerebrovascular Disease: Implications for Pathophysiology and Treatment 1180
Index 1193

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