Ioachim's Lymph Node Pathology 5e > Surgical Pathology

Fully revised and up- to- date, Ioachim's Lymph Node Pathology, 5th Edition, offers valuable guidance in the diagnostic interpretation of lymph node biopsies. Continuing the tradition of excellence established by Dr. Harry L. Ioachim, Dr. L. Jeffrey Medeiros of The University of Texas MD Anderson Cancer Center offers a comprehensive, clinically useful approach to all the various nonmalignant lesions, lymphomas, other neoplasms, and metastatic tumors in lymph nodes. Discussion of each pathologic entity includes definition, clinical syndrome, histopathology, immunopathology, molecular genetic findings, and differential diagnosis. In addition, chapters have a useful checklist for each entity.

“Brings together the background information, the morphologic descriptions, the recommended procedures, the supportive illustrations, and the interpretation of results necessary to make the correct diagnosis.” (from the Preface to the fourth edition)

Features expanded information on the methods of flow cytometry, immunohistochemistry, and molecular diagnosis.

Contains more than 700 high-quality illustrations, including over 600 in full color.

Includes sections on normal lymph node; diagnostic methods; lymphadenitides; lymphadenopathies; lymphomas; lymphoproliferative disorders associated with immune deficiencies; dendritic cell, histiocytic and granulocytic/monocytic neoplasms; spindle cell neoplasms of lymph nodes; vascular neoplasms of lymph nodes; and metastatic tumors in lymph nodes.

Incorporates guidelines of the revised fourth edition of the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues.

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CONTENTS
Preface xiii
Preface to the First Edition xv
Acknowledgments xvii
PART ONE NORMAL LYMPH NODE
Chapter 1 Normal Lymph Node 2
PART TWO DIAGNOSTIC METHODS
Chapter 2 The Lymph Node Biopsy 16
Chapter 3 Cytopathology 24
Chapter 4 Electron Microscopy 38
Chapter 5 Flow Cytometry 43
Chapter 6 Immunohistochemistry 57
Chapter 7 Molecular Assessment of Clonality 68
Chapter 8 Molecular Assessment of Genetic Abnormalities 77
PART THREE LYMPHADENITIDES
SECTION I VIRAL LYMPHADENITIDES
Chapter 9 Infectious Mononucleosis Lymphadenitis 96
Chapter 10 Cytomegalovirus Lymphadenitis 104
Chapter 11 Herpes Simplex Virus Lymphadenitis 108
Chapter 12 Varicella-Zoster Viral Lymphadenitis 114
Chapter 13 Vaccinial Lymphadenitis 119
Chapter 14 Measles Lymphadenitis 122
Chapter 15 Human Immunodeficiency Virus Lymphadenitis 126
SECTION II BACTERIAL LYMPHADENITIDES
Chapter 16 Ordinary Bacterial Lymphadenitis 134
Chapter 17 Cat-Scratch Lymphadenitis 138Chapter 18 Bacillary Angiomatosis 144
Chapter 19 Lymphogranuloma Venereum Lymphadenitis 149
Chapter 20 Syphilitic Lymphadenitis 154
Chapter 21 Lymphadenitis of Whipple Disease 160
SECTION III MYCOBACTERIAL LYMPHADENITIDES
Chapter 22 Mycobacterium Tuberculosis Lymphadenitis 165
Chapter 23 Nontuberculous Mycobacterial Lymphadenitis 173
Chapter 24 Mycobacterium Leprae Lymphadenitis 182
SECTION IV FUNGAL LYMPHADENITIDES
Chapter 25 Cryptococcus Lymphadenitis 187
Chapter 26 Histoplasma Lymphadenitis 191
Chapter 27 Coccidioidomycosis Lymphadenitis 196
Chapter 28 Pneumocystis Lymphadenitis 200
SECTION V PROTOZOAL LYMPHADENITIDES
Chapter 29 Toxoplasma Lymphadenitis 204
Chapter 30 Leishmania Lymphadenitis 210
Chapter 31 Filaria Lymphadenitis 216
PART FOUR LYMPHADENOPATHIES
SECTION I REACTIVE LYMPHADENOPATHIES
Chapter 32 Reactive Lymphoid Hyperplasia 220
Chapter 33 Progressive Transformation of Germinal Centers 230
SECTION II L YMPHADENOP A THIES ASSOCIA TED WITH
CLINICAL SYNDROMES
Chapter 34 IgG4-Related Lymphadenopathy 236
Chapter 35 Kimura Lymphadenopathy 242
Chapter 36 Rosai-Dorfman Disease 246
Chapter 37 Kikuchi-Fujimoto Disease 252
Chapter 38 Sarcoidosis Lymphadenopathy 259
Chapter 39 Systemic Lupus Lymphadenopathy 269
Chapter 40 Rheumatoid Lymphadenopathy 275
Chapter 41 Dermatopathic Lymphadenopathy 281
Chapter 42 Unicentric Castleman Disease 286
Chapter 43 Multicentric Castleman Disease 295
Chapter 44 Tumor-Reactive Lymphadenopathy 304
Chapter 45 Amyloid Lymphadenopathy 311SECTION III LYMPHADENOPATHY ASSOCIATED WITH
DRUG THERAPY
Chapter 46 Drug-Induced Lymphadenopathy 316
SECTION IV VASCULAR LYMPHADENOPATHIES
Chapter 47 Lymph Node Infarction 322
Chapter 48 Vascular Transformation of Sinuses 326
SECTION V FOREIGN BODY LYMPHADENOPATHIES
Chapter 49 Lipogranulomatous Lymphadenopathy 329
Chapter 50 Silicone Lymphadenopathy 334
Chapter 51 Lymphadenopathy Associated With Joint Prostheses 338
Chapter 52 Tattoo Lymphadenopathy 341
Chapter 53 Gold Lymphadenopathy 345
SECTION VI LYMPH NODE INCLUSIONS
Chapter 54 Epithelial Cell Inclusions in Lymph Nodes 347
Chapter 55 Nevus Cell Inclusions in Lymph Nodes 353
PART FIVE LYMPHOMAS
SECTION I NOMENCLA TURE AND CLASSIFICA TION
OF LYMPHOMAS
Chapter 56 Nomenclature and Classification of Lymphomas 358
SECTION II HODGKIN LYMPHOMAS
Chapter 57 Classic Hodgkin Lymphomas 369
Chapter 58 Nodular Lymphocyte–Predominant Hodgkin Lymphoma 386
SECTION III PRECURSOR LYMPHOID NEOPLASMS
Chapter 59 B Lymphoblastic Leukemia/Lymphoma 396
Chapter 60 T Lymphoblastic Lymphoma/Leukemia 404
SECTION IV MATURE B-CELL NEOPLASMS
Chapter 61 Chronic Lymphocytic Leukemia/Small
Lymphocytic Lymphoma 417
Chapter 62 Lymphoplasmacytic Lymphoma and Waldenstrom
Macroglobulinemia 428
Chapter 63 Hairy Cell Leukemia 442
Chapter 64 Nodal Marginal Zone B-Cell Lymphoma 453
Chapter 65 Extranodal Marginal Zone Lymphomas 462
Chapter 66 Splenic Marginal Zone Lymphoma 469
Chapter 67 Plasmacytoma 474Chapter 68 Follicular Lymphoma 479
Chapter 69 Mantle Cell Lymphoma 496
Chapter 70 Diffuse Large B-Cell Lymphoma 513
Chapter 71 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma 531
Chapter 72 ALK-Positive Large B-Cell Lymphoma 537
Chapter 73 Plasmablastic Lymphoma 541
Chapter 74 Primary Mediastinal Large B-Cell Lymphoma 546
Chapter 75 Epstein-Barr Virus–Positive Diffuse
Large B-Cell Lymphoma, Not Otherwise Specified 553
Chapter 76 HHV8-Positive Lymphoproliferative Disorders 558
Chapter 77 Extranodal Variants of Diffuse Large B-Cell Lymphoma 566
Chapter 78 Burkitt Lymphoma 580
Chapter 79 High-Grade B-Cell Lymphomas 593
Chapter 80 B-Cell Lymphoma, Unclassifiable, With Features
Intermediate Between Diffuse Large B-Cell
Lymphoma and Classic Hodgkin Lymphoma 603
Chapter 81 Composite Lymphoma 609
SECTION V MATURE T-CELL NEOPLASMS
Chapter 82 Peripheral T-Cell Lymphoma, Not Otherwise Specified 618
Chapter 83 Angioimmunoblastic T-Cell Lymphoma 630
Chapter 84 Peripheral T-Cell Lymphoma With T Follicular
Helper Cell Immunophenotype 644
Chapter 85 Adult T-Cell Leukemia/Lymphoma 650
Chapter 86 Mycosis Fungoides and Sézary Syndrome 662
Chapter 87 ALK-Positive Anaplastic Large-Cell Lymphoma 681
Chapter 88 ALK-Negative Anaplastic Large-Cell Lymphoma 695
Chapter 89 Extranodal Anaplastic Large-Cell Lymphomas 703
PART SIX LYMPHOPROLIFERATIVE DISORDERS ASSOCIATED WITH
IMMUNE DEFICIENCIES
Chapter 90 Lymphoproliferative Disorders Associated With
Primary Immunodeficiency Syndromes 714
Chapter 91 Iatrogenic Lymphoproliferative Disorders 724
Chapter 92 Posttransplant Lymphoproliferative Disorders 735
Chapter 93 Lymphomas Associated With Human
Immunodeficiency Virus Infection 748PART SEVEN DENDRITIC CELL AND HISTIOCYTIC AND
GRANULOCYTIC/MONOCYTIC NEOPLASMS
Chapter 94 Follicular Dendritic Cell Sarcoma 756
Chapter 95 Interdigitating Dendritic Cell Sarcoma 762
Chapter 96 Langerhans Cell Histiocytosis and Langerhans
Sarcoma 767
Chapter 97 Histiocytic Sarcoma 777
Chapter 98 Myeloid Sarcoma 784
Chapter 99 Blastic Plasmacytoid Dendritic Cell Neoplasm 794
Chapter 100 Mastocytosis 801
PART EIGHT SPINDLE CELL NEOPLASMS OF LYMPH NODES
Chapter 101 Intranodal Palisaded Myofibroblastoma 812
Chapter 102 Inflammatory Pseudotumor of Lymph Nodes 815
PART NINE VASCULAR NEOPLASMS OF LYMPH NODES
Chapter 103 Vascular Neoplasms of Lymph Nodes 820
Chapter 104 Kaposi Sarcoma 824
PART TEN METASTATIC TUMORS IN LYMPH NODES
Chapter 105 Tumor Metastases in Lymph Nodes 832
Chapter 106 Metastatic Melanoma 846
Chapter 107 Metastatic Breast Carcinoma 854
Chapter 108 Metastatic Nasopharyngeal Carcinoma 865
Chapter 109 Metastatic Thyroid Carcinoma 871
Chapter 110 Metastatic Renal Cell Carcinoma 879
Chapter 111 Metastatic Seminoma 885
Chapter 112 Metastatic Prostate Carcinoma 890
Chapter 113 Metastatic Mucinous Adenocarcinoma 896
Chapter 114 Metastatic Neuroendocrine Tumors 901
Chapter 115 Metastatic Neuroblastoma 908
Chapter 116 Metastatic Ewing Sarcoma 915
Chapter 117 Metastatic Rhabdomyosarcoma 920
Index 927