Clinical Immunology,6/e > Immunology

Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; and includes complete coverage of all common and less common disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume.

Key Features

Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine.  

Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T-cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically-focused chapter on asthma.

Provides new genetics content focused on data applications.

Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. 

Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.

Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.

Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussions of translational research.

Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Author Information

Edited by Robert R. Rich, MD, Professor of Medicine and Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA; Thomas A. Fleisher, MD, FAAAAI, FACAAI, Adjunct Professor of Pediatrics, USUHA, Chief, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda MD, USA; Harry W. Schroeder Jr., II, MD, PhD, Professor of Medicine, Microbiology, and Genetics, Division of Clinical Immunology and Rheumatology, Director, UAB Program in Immunology, University of Alabama at Birmingham, Birmingham, AL, USA; Cornelia M. Weyand, MD, PhD, Professor of Medicine, Stanford University School of Medicine, Department of Medicine: Immunology and Rheumatology, Stanford, CA, USA ; David B. Corry and Jennifer M. Puck

1 The human immune response
2 Organization of the immune system
3 Innate immunity
4 Antigen receptor genes, gene products, and co-receptors/
5 The major histocompatibility complex
6 Antigens and Antigen Presentation
7 B-cell development and differentiation
8 Immunoglobulin Function
9 T-Cell Development
10 T-Cell Activation and Tolerance
11 Helper T-Cell Subsets and Control of the Inflammatory Response
12 Cytotoxic T Lymphocytes and Natural Killer Cells?
13 Regulatory Immune Cells
14 Cytokines and cytokine receptors
15 Chemokines and chemokine receptors
16 Lymphocyte adhesion and trafficking
17 Death Pathways and Immunogenicity
18 T-cell activation and tolerance
18 Regulated cell death
18 The Microbiota in Immunity and Inflammation
18 Human Genomics in Immunology
19 Regulatory RNA in Immunologic Diseases
20 Immunometabolism
21 Immune Deficiencies at the Extremes of Age
22 Nutritional Modulation of Immune Function
22 The Microbiota in Immunity and Inflammation
23 Immunology of the Skin
24 Immunology of Mucosal Surfaces
24 Complement in host deficiencies and diseases
24 Phagocyte deficiencies
24 Mast cells, basophils, and mastocytosis
24 Eosinophils and eosinophilia
25 Host defenses to viruses
26 Host defenses to intracellular bacteria
27 Host defenses to extracellular bacteria including Spirochetes
28 Host Defenses to Fungi
29 Host defenses to spirochetes
29 Host defenses to protozoa
30 Host defenses to helminth infections
31 Emerging Pandemic Infectious Disease Threats
32 Approach to the Evaluation of the Patient with Suspected Immunodeficiency
33 Human Genomics in Immunology
33 Primary antibody deficiencies
34 Primary T-cell immunodeficiencies
35 Genetic disorders of IFNs-, IL-17, IL-18 and NF-?B-mediated immunity
36 Hemophagocytic Lymphohistiocytosis
37 Autoinflammatory Syndromes
38 Immune Activation Disorders
39 Neutrophils and Neutrophil Disorders
40 Complement and Complement Disorders
41 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
42 Autoantibody Mediated Phenocopies of Primary Immunodeficiency Diseases
43 Allergic Airway Disease
44 Mast Cells and Mast Cell Disorders
45 Eosinophils and Eosinophilic Disorders
46 Urticaria, angioedema, and anaphylaxis¡
47 Allergic reactions to stinging and biting insects
48 Atopic and contact dermatitis
49 Food allergy
50 Drug Hypersensitivity
51 Allergic disorders of the eye
51 Drug hypersensitivity
51  Occupational Respiratory Allergies
51 Mechanisms of autoimmunity
52 Systemic lupus erythematosus
53 Rheumatoid arthritis
54 Juvenile idiopathic arthritis
55 Sjögren syndrome
56 Scleroderma-systemic sclerosis
57 Inflammatory muscle diseases
58 Spondyloarthritis
59 Small and medium vessel primary vasculitis
60 Large-vessel vasculitides
61 Systemic autoinflammatory syndromes
61 Antiphospholipid syndrome
62 Immunohematologic disorders
63 Bullous diseases of the skin and mucous membranes
64 Immunology of psoriasis
65 Myasthenia gravis
66 Multiple sclerosis
67 Autoimmune peripheral neuropathies
68 Immunologic renal diseases
69 Immunologic Diseases of the Cardiovascular System
70 Autoimmune thyroid diseases
71 Type 1 Diabetes
72 Immunologic lung diseases
73 Chronic Obstructive Pulmonary Disease and Emphysema
74 Immunologic ocular disease
75 Immunologic diseases of the gastrointestinal tract
76 Inflammatory hepatobiliary diseases
77 Tumor immunotherapy
77 Lymphoid leukemias
78 Lymphomas
79 Monoclonal gammopathies
80 Immune Responses to Solid Tumors and Immune Checkpoint tTerapy
81 CAR T-Cell Therapy
82 Immunoglobulin Therapy: Replacement and Immunomodulation
83 Glucocorticoids
84 Immunomodulating Drugs
85 Protein Kinase Antagonists
86 Biologic Response Modifiers
87 Vaccines
88 Allergen Immunotherapy of Allergic Disease
89 Solid Organ Transplantation: Rejection, Immunosuppression and Tolerance
89 Immune Checkpoint Therapy
90 Allogeneic Transplantation for Immunodeficiency
91 Gene Therapy fo Primary Immune deficiency Diseases
92 Hematopoietic Stem Cell Transplantation for Malignant Diseases
93 Flow cytometry
94 Biological Modifiers of Inflammation
94 Vaccines
94 Immunotherapy of allergic disease
94 Assessment of Functional Immune Responses in Lymphocytes
95 Assessment of neutrophil function
96 Assessment of human allergic diseases
 App1 -  Selected CD molecules and their characteristics
 App2 -  Laboratory reference values
98 Molecular methods
98 A3: Vaccine schedules