Plotkin's Vaccines,8/e > Infectious Disease

From the latest vaccination evidence, recommendations, and protocols . . . to new vaccine development and the use of vaccines in reducing disease, Plotkin’s Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin’s Vaccines is a must-have reference for current, authoritative information in this fast-moving field.

Key Features

Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization.

Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines.

Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality.

Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues.

Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies.

Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues.

Analyzes the cost-benefit and cost-effectiveness of different vaccine options.

Helps you clearly visualize concepts and objective data through an abundance of tables and figures.

Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.


Author Information

By Walter A. Orenstein, MD, DSc (HON), Professor of Medicine and Pediatrics, and Global Health, Emory University; Associate Director, Emory Vaccine Center, Atlanta GA; Bill & Melinda Gates Foundation, Seattle, WA; Former Director, National Immunization Program, Centers for Disease Control and Prevention, Atlanta GA ; Paul A. Offit, MD, Chief, Division of Infectious Diseases, Director, Vaccine Education Center, The Children's Hospital of Philadelphia; Professor of Pediatrics, Maurice R. Hilleman Professor of Vaccinology, Perelman School of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Kathryn M. Edwards, MD, Sarah H. Sell and Cornelius Vanderbilt Chair in Pediatrics, Professor of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee and Stanley A. Plotkin, MD, Emeritus Professor of Pediatrics, University of Pennsylvania, Emeritus Professor, Wistar Institute, Former Chief, Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, PA; Former Medical and Scientific Director, Pasteur Merieux Connaught (now Sanofi Pasteur), Marnes-la-Coquette, France 

Section 1: General Aspects of Vaccination

1 A short history of vaccination
2 Vaccine immunology
3 Non-specific effects of Vaccines
4 Correlates of protection
5 The vaccine industry
6 Vaccine manufacturing
7 Evolution of adjuvants across the centuries
8 Vaccine Additives and Manufacturing Residuals in Vaccines Licensed in the United States
9 Passive immunization

 Section 2: Licenced Vaccines and Vaccines in Development

10 General immunization practices
11 Human Adenovirus vaccines
12 Anthrax vaccines
13 EMERGING Diseases and  Emerging VACCINES (Military)
14 Cancer vaccines
15 Cholera vaccines
16 Combination vaccines
17 Coronavirus
18 Cytomegalovirus vaccines
19 Dengue vaccines
20 Diarrhea caused by bacteria
21 Diphtheria toxoid
22 Ebola vaccines
23 Enterovirus
24 Epstein-Barr virus vaccines
25 Haemophilus influenzae type b vaccines
26 Hepatitis A vaccines
27 Hepatitis B vaccines
28 Hepatitis C vaccines
29 Hepatitis E vaccines
30 Herpes simplex virus vaccines
31 Human immunodeficiency virus vaccines
32 Human papillomavirus vaccines
33 Inactivated influenza vaccines
34 Influenza vaccine—live
35 Japanese encephalitis vaccines
36 Lyme disease vaccines
37 Malaria vaccines
38 Measles vaccine
39 Meningococcal Capsular A, B, C, W, and Y Conjugate Vaccines
40 Meningococcal Capsular B Vaccines
41 Mumps vaccines
42 Noninfectious disease vaccines
43 Norovirus
44 Norovirus
44 Parasitic disease vaccines
45 Pertussis vaccines
46 Plague vaccines
47 Pneumococcal conjugate vaccine and pneumococcal common protein vaccines
48 Pneumococcal polysaccharide vaccines
49 Poliovirus vaccine—inactivated
50 Poliovirus vaccine—live
51 Rabies vaccines
52 Respiratory syncytial virus vaccines
53 Rotavirus vaccines
54 Rubella vaccine
55 Smallpox and vaccinia
56 Staphylococcus aureus vaccines
57 Streptococcus group A vaccines
58 Streptococcus group B vaccines
59 Tetanus toxoid
60 Tick-borne encephalitis virus vaccines
61 Tuberculosis vaccines
62 Typhoid fever vaccines
63 Varicella vaccine
64 Yellow fever vaccine
65 Zika vaccine
66 Zoster vaccine
67 Technologies for making new vaccines

Section 3: New Technologies

68 The development of gene-based vectors for immunization
69 Technologies to Improve Immunization
70 Vaccination of immunocompromised hosts

Section 4: Vaccination in Special Groups

71 Vaccines for international travel
72 Vaccines for health care personnel
73 Vaccination of pregnant women
74 Vaccination of pregnant women
74 Immunization in the United States
75 Immunization in Europe

Section 5: Public Health and Regulatory Issues

76 Immunization in the Asia-Pacific region
77 Immunization in developing countries
78 Community Protection
79 Economic analyses of vaccine policies
80 Regulation and testing of vaccines IN THE US
81 Regulation of vaccines in Europe
82 Regulation of vaccines in low and middle-income countries
83 Vaccine safety
84 Vaccine hesitancy
85 Legal issues
86 Ethics
 Appendix