For nearly 60 years, Heptinstall’s Pathology of the Kidney has been the reference of choice for both pathologists and nephrologists for expert, authoritative coverage of kidney disease. The fully revised and reorganized Eighth Edition, edited by Drs. J. Charles Jennette, Vivette D. D’Agati, Agnes B. Fogo, Volker Nickeleit and Michael Barry Stokes offers thorough pathologic descriptions, important clinical correlations, and up-to-date discussions of causes and pathogenesis to improve understanding of kidney disease and to facilitate accurate diagnosis and optimum care of patients with kidney disease. Now in a single volume, this image-rich text conveys the unique challenges and intricacies of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research.
Features a completely reorganized, single volume format, with more than 60 concise chapters covering all kidney diseases
Provides comprehensive yet concise information on pathology, differential diagnosis and clinicopathologic correlations, as well as useful overviews of pathogenesis, demographics/epidemiology, and relevant clinical presentation, treatment, and outcomes
Contains numerous diagnostic algorithms throughout
Offers clinically oriented, quick-reference content on patterns of injury and classification
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Contributors vii
Preface ix
Tribute xi
Preface to the First Edition (1966) xiii
Acknowledgments xv
SECTION 1
Introduction to
Kidney Pathology 1
1.1
Kidney Pathology History and Kidney
Biopsy Methods 2
J. Charles Jennette, Vivette D. D’Agati, M. Barry Stokes,
Agnes B. Fogo, and Volker Nickeleit
1.2
Primer on the Pathologic Classification
and Diagnosis of Kidney Disease 8
J. Charles Jennette, Vivette D. D’Agati, Agnes B. Fogo,
Volker Nickeleit, and M. Barry Stokes
SECTION 2
Kidney Anatomy, Histology,
and Development 43
2.1
Kidney Anatomy and Histology 44
William L. Clapp
2.2
Kidney Development 143
Filipa M. Lopes and Adrian S. Woolf
SECTION 3
Kidney Congenital Anomalies
and Cystic Diseases 169
3.1
Patterns of Injury, Terminology, and
Classification of Kidney Congenital
Anomalies and Cystic Diseases 170
Helen Liapis and J. Charles Jennette
3.2
Kidney Congenital Anomalies Including
Dysplasia 177
Helen Liapis and Sanjay Jain
3.3
Cystic Kidney Disease 195
Helen Liapis and Bharathi V. Reddy
SECTION 4
Glomerular Disease Associated
With Proteinuria and Nephrotic
Syndrome 215
4.1
Patterns of Injury, Terminology, and
Classification of Glomerular Diseases
Associated With Proteinuria and Nephrotic
Syndrome 216
Vivette D. D’Agati and J. Charles Jennette
4.2
Minimal Change Disease 234
M. Barry Stokes
4.3
Focal Segmental Glomerulosclerosis 275
Vivette D. D’Agati and M. Barry Stokes
4.4
Membranous Nephropathy 334
Glen S. Markowitz, Sanjeev Sethi, and Vivette D. D’Agati
4.5
Amyloidosis 391
Maria M. Picken and Guillermo A. Herrera
4.6
Monoclonal Immunoglobulin-Related
Glomerular Disease 424
Sanjeev Sethi, Fernando C. Fervenza, and Samih H. Nasr
4.7
Immunotactoid Glomerulopathy 466
Samih H. Nasr, Fernando C. Fervenza, and Sanjeev Sethi
4.8
Diabetic Kidney Disease 477
Behzad Najafian and Charles E. Alpers
4.9
Idiopathic Nodular Glomerulosclerosis 518
M. Barry Stokes and Vivette D. D’Agati
4.10
Metabolic and Storage Disease
Glomerulopathies 526
Laura S. Finn
4.11
Fibronectin Glomerulopathy 560
Megan Troxell and Neeraja Kambham
4.12
Collagenofibrotic Glomerulopathy
and Nail-Patella Syndrome 567
Laura S. Finn and Agnes B. FogoSECTION 5
Glomerular Disease Associated
With Hematuria and Nephritic
Syndrome 577
5.1
Patterns of Injury, Terminology, and
Classification of Glomerular Diseases
Associated With Hematuria and Nephritic
Syndrome 578
J. Charles Jennette and Vivette D. D’Agati
5.2
IgA Nephropathy and IgA Vasculitis
(Henoch-Schönlein Purpura) Nephritis 591
Mark Haas
5.3
Lupus Nephritis and Related Autoimmune
Diseases 661
Vivette D. D’Agati and M. Barry Stokes
5.4
Fibrillary Glomerulonephritis 740
Kelly D. Smith
5.5
Cryoglobulinemic Glomerulonephritis 750
Ian W. Gibson and Volker Nickeleit
5.6
Acute Post-infectious Glomerulonephritis
and Infection-Associated
Glomerulonephritis 763
Anjali A. Satoskar and Tibor Nadasdy
5.7
C3 Glomerulopathy 823
H. Terence Cook and Matthew C. Pickering
5.8
Anti–Glomerular Basement Membrane
Disease 848
J. Charles Jennette and Ingeborg M. Bajema
5.9
Antineutrophil Cytoplasmic Autoantibody
Disease 874
J. Charles Jennette and Ingeborg M. Bajema
5.10
Alport Syndrome/Type IV Collagen
Nephropathies 903
Agnes B. Fogo
SECTION 6 Kidney Vasculopathies 923
6.1
Patterns of Injury, Classification,
and Diagnostic Algorithm of Kidney
Vasculopathies 924
M. Barry Stokes and J. Charles Jennette
6.2
Kidney Disease Related to Hypertension
and Age 937
Agnes B. Fogo
6.3
Fibromuscular Dysplasia 967
Surya V. Seshan and J. Charles Jennette
6.4
Thrombotic Microangiopathies 973
Kerstin Amann and Agnes B. Fogo
6.5
Preeclampsia and Other Pregnancy-
Associated Kidney Disease 1033
Agnes B. Fogo
6.6
Disseminated Intravascular
Coagulation 1068
Kerstin Amann and Agnes B. Fogo
6.7
Atherosclerosis and Embolic Kidney
Disease 1071
Hans-Joachim Anders and Agnes B. Fogo
6.8
Polyarteritis Nodosa, Kawasaki Disease,
Takayasu Arteritis, and Giant Cell
Arteritis 1078
Surya V. Seshan and J. Charles Jennette
SECTION 7 Tubulointerstitial Disease 1107
7.1
Patterns of Injury, Terminology, and
Classification of T ubulointerstitial
Disease 1108
Agnes B. Fogo and J. Charles Jennette
7.2
Infection-Related T ubulointerstitial
Nephritis 1122
Megan Troxell and Neeraja Kambham
7.3
Noninfectious T ubulointerstitial
Nephritis 1168
Cynthia C. Nast and Agnes B. Fogo
7.4
IgG4-Related Disease 1204
Lynn D. Cornell
7.5
Chronic Interstitial Nephritis in
Agricultural Communities (Mesoamerican
Nephropathy, CKDu) and Aristolochic
Acid Nephropathy (Balkan Endemic
Nephropathy) 1216
Cynthia C. Nast and Marc E. De Broe
7.6
Nephronophthisis, Medullary Cystic
Disease, and Other Genetic T ubular
Disease 1232
Laura S. Finn 7.7
Ischemic and Septic Acute T ubular Injury
and Cortical Necrosis 1262
Joseph P . Gaut
7.8
Nephrotoxic Acute T ubular Injury 1284
Gilbert W. Moeckel
7.9
Light Chain Tubulopathies 1310
M. Barry Stokes
7.10
Light Chain (Myeloma) Cast Nephropathy
and Mimics 1317
Virginie Royal and Guillermo A. Herrera
7.11
Myoglobin, Hemoglobin, and Bile
Cast Nephropathies, and Anticoagulant
Nephropathy 1329
Joseph P . Gaut, Sergey V. Brodsky, and Tibor Nadasdy
7.12
Nephrolithiasis and Crystallopathies 1344
Laura S. Finn and Hans-Joachim Anders
7.13
Obstructive and Reflux Nephropathy 1366
Lois J. Arend
SECTION 8 Transplant Pathology 1383
8.1
Patterns of Injury, Terminology, and
Classification of Kidney T ransplant
Disease 1384
Volker Nickeleit and J. Charles Jennette
8.2
Kidney Allograft Biopsy: Overview 1393
Volker Nickeleit
8.3
Donor Kidney Biopsies 1396
Harsharan K. Singh and Volker Nickeleit
8.4
Kidney Transplant Rejection 1402
Volker Nickeleit, Robert B. Colvin, and Peter Nickerson
8.5
Kidney T ransplant Ischemic Injury 1479
Parmjeet Randhawa
8.6
Kidney T ransplant: Drug T oxicity 1485
Volker Nickeleit and Parmjeet Randhawa
8.7
Kidney Transplant Infection 1501
Harsharan K. Singh and Volker Nickeleit
8.8
Recurrent and De Novo Disease 1521
Parmjeet Randhawa and Volker Nickeleit
8.9
Posttransplant Lymphoproliferative
Disorders 1537
Parmjeet Randhawa and Volker Nickeleit
8.10
Kidney T ransplant: Surgical and Vascular
Complications 1545
Parmjeet Randhawa and Volker Nickeleit
SECTION 9 Kidney Neoplasms 1551
9.1
Patterns of Injury, Terminology, and
Classification of Kidney Neoplasms 1552
John N. Eble, Liang Cheng, and J. Charles Jennette
9.2
Kidney Neoplasms in Children 1558
John N. Eble and Liang Cheng
9.3
Kidney Neoplasms in Adults 1567
John N. Eble and Liang Cheng
Index 1601
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