Widely considered the premier text in pediatric infectious diseases, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, 9th Edition: 2-Volume Set, provides authoritative, up-to-date coverage of this rapidly changing field. Extensively revised by Drs. James Cherry, Sheldon L. Kaplan, Gail J. Demmler-Harrison, William J. Steinbach, Peter J. Hotez, and new editor John V. Williams, this two-volume reference delivers the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. It serves as a reliable, everyday resource for practicing ID specialists, and an invaluable reference for medical students, residents, and fellows in ID, pediatricians and internists, and others who work with neonates, children, and adolescents or in public health.
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Edited by James Cherry, MD, MSc, Distinguished Professor of Pediatrics, David Geffen School of Medicine at UCLA; Attending Physician, Pediatric Infectious Diseases, Mattel Children’s Hospital UCLA, Los Angeles, California; Sheldon L. Kaplan, MD, Professor, Division of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine; Attending Physician, Infectious Disease Service, Texas Children’s Hospital, Houston, Texas; Gail J. Demmler-Harrison, MD, Professor, Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine; Attending Physician, Infectious Diseases Service, Texas Children’s Hospital, Houston, Texas; William Steinbach, MD, Professor of Pediatrics, Robert H. Fiser, Jr., MD Endowed Chair in Pediatrics, Chair, Department of Pediatrics, Associate Dean for Child Health, College of Medicine, University of Arkansas for Medical Sciences; Pediatrician-in-Chief, Arkansas Children’s Little Rock, Arkansas; Peter J Hotez, MD, PhD, Dean, National School of Tropical Medicine, Professor, Pediatrics and Molecular Virology &; Microbiology, Baylor College of Medicine; Endowed Chair of Tropical Pediatrics, Texas Children’s Hospital, Houston, Texas and John V Williams, MD, Professor, Pediatrics and Microbiology &; Molecular Genetics, Henry L. Hillman Professor of Pediatric Immunology, Chief, Pediatric Infectious Diseases, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
VOLUME ONE
PART I Host-Parasite Relationships and the Pathogenesis of Infectious Diseases
1 Molecular Determinants of Microbial Pathogenesis
2 Normal and Impaired Immunologic Responses to Infection
3 The Host Response to Infections: The “-omics” Revolution
4 Fever: Pathogenesis and Treatment
5 The Human Microbiome
6 Epidemiology and Biostatistics of Infectious Diseases
PART II Infection of Specific Organ Systems
SECTION 1 Upper Respiratory Tract Infections
7 The Common Cold
8 Infections of the Oral Cavity
9 Pharyngitis (Pharyngitis, Tonsillitis, Tonsillopharyngitis, and Nasopharyngitis)
10 Uvulitis
11 Peritonsillar, Retropharyngeal, and Parapharyngeal Abscesses
12 Cervical Lymphadenitis
13 Parotitis
14 Rhinosinusitis
15 Otitis Externa
16 Otitis Media
17 Mastoiditis
18 Croup (Laryngitis, Laryngotracheitis, Spasmodic Croup, Laryngotracheobronchitis, Bacterial Tracheitis, and Laryngotracheobronchopneumonitis) and Epiglottitis (Supraglottitis)
SECTION 2 Lower Respiratory Tract Infections
19 Acute Bronchitis
20 Chronic Bronchitis
21 Bronchiolitis and Infectious Asthma
22 Pediatric Community-Acquired Pneumonia
23 Empyema and Lung Abscess
24 Children’s Interstitial Lung Disease and Hypersensitivity Pneumonitis
25 Cystic Fibrosis
SECTION 3 Infections of the Heart
26 Infective Endocarditis
27 Infectious Pericarditis
28 Myocarditis
29 Acute Rheumatic Fever
30 Mediastinitis
SECTION 4 Central Nervous System Infections
31 Bacterial Meningitis Beyond the Neonatal Period
32 Parameningeal Infections
33 Fungal Meningitis
34 Eosinophilic Meningitis
35 Aseptic Meningitis and Viral Meningitis
36 Encephalitis and Meningoencephalitis
37 Parainfectious and Postinfectious Demyelinating Disorders of the Central Nervous System
38 Infection-Associated Myelitis and Myelopathies of the Spinal Cord
39 Guillain-Barré Syndrome
SECTION 5 Genitourinary Tract Infections
40 Urethritis
41 Cystitis and Pyelonephritis
42 Renal Abscess
43 Prostatitis
44 Female Genital Infections
SECTION 6 Gastrointestinal Tract Infections
45 Esophagitis
46 Approach to Patients With Gastrointestinal Tract Infections and Food Poisoning
47 Clostridioides difficile Infection
48 Whipple Disease
SECTION 7 Liver Diseases
49 Hepatitis
50 Cholangitis and Cholecystitis
51 Pyogenic Liver Abscess
52 Reye Syndrome
SECTION 8 Other Intraabdominal Infections
53 Appendicitis and Pelvic Abscess
54 Pancreatitis
55 Peritonitis and Intraabdominal Abscess
56 Retroperitoneal Infections
SECTION 9 Musculoskeletal Infections
57 Osteomyelitis
58 Septic Arthritis
59 Bacterial Myositis and Pyomyositis
SECTION 10 Skin Infections
60 Cutaneous Manifestations of Systemic Infections
61 Roseola Infantum (Exanthem Subitum)
62 Bacterial Skin Infections
SECTION 11 Ocular Infectious Diseases
64 Ocular Infections
SECTION 12 Systemic Infectious Diseases
65 Bacteremia and Septic Shock
66 Fever Without Source and Fever of Unknown Origin
67 Toxic Shock Syndrome
SECTION 13 Infections of the Fetus and Newborn
68 Approach to Infections in the Fetus and Newborn
SECTION 14 Infections of the Compromised Host
69 Inborn Errors of Immunity (Primary Immunodeficiencies)
70 The Febrile Neutropenic Patient
71 Opportunistic Infections in Hematopoietic Stem Cell Transplantation
72 Infections in Pediatric Heart Transplantation
73 Infections in Pediatric Lung Transplantation
74 Opportunistic Infections in Liver and Intestinal Transplantation
75 Infections in Renal Transplantation
76 Infections Related to Prosthetic or Artificial Devices
77 Infections in Burn Patients
SECTION 15 Unclassified Infectious Diseases
78 Kawasaki Disease
79 Chronic Fatigue Syndrome (Systemic Exertion Intolerance Disease)
PART III Infections With Specific Microorganisms
SECTION 16 Bacterial Infections
SUBSECTION I Gram-Positive Cocci
80 Staphylococcus aureus Infections (Coagulase-Positive Staphylococci)
81 Coagulase-Negative Staphylococcal Infections
82 Group A, Group C, and Group G ß-Hemolytic Streptococcal Infections
83 Group B Streptococcal Infections
84 Enterococcal and Viridans Streptococcal Infections
85 Pneumococcal Infections
86 Miscellaneous Gram-Positive Cocci
SUBSECTION II Gram-Negative Cocci
87 Moraxella catarrhalis
88 Meningococcal Disease
89 Gonococcal Infections
SUBSECTION III Gram-Positive Bacilli
90 Diphtheria
91 Anthrax
92 Bacillus cereus and Other Bacillus Species
93 Arcanobacterium haemolyticum
94 Erysipelothrix rhusiopathiae
95 Listeriosis
96 Tuberculosis
97 Other Mycobacteria
98 Leprosy and Buruli Ulcer: The Major Cutaneous Mycobacterioses
99 Nocardia
100 Corynebacterium and Rhodococcus
SUBSECTION IV Gram-Negative Bacilli
101 Citrobacter
102 Enterobacter
103 Extraintestinal Pathogenic Escherichia coli
104 Diarrhea-Causing and Dysentery-Causing Escherichia coli
105 Klebsiella
106 Morganella morganii
107 Proteus
108 Providencia
109 Shigella
110 Serratia
111 Salmonella
112 Plague (Yersinia pestis)
113 Other Yersinia Species
114 Miscellaneous Enterobacteriaceae
115 Aeromonas
116 Pasteurella multocida
117 Cholera
118 Vibrio parahaemolyticus
119 Vibrio vulnificus
120 Miscellaneous Non-Enterobacteriaceae Fermentative Bacilli
121 Acinetobacter
122 Achromobacter (Alcaligenes)
123 Eikenella corrodens
124 Elizabethkingia and Chryseobacterium Species
125 Pseudomonas and Related Genera
126 Stenotrophomonas (Xanthomonas) maltophilia
SUBSECTION V Gram-Negative Coccobacilli
127 Aggregatibacter Species
128 Brucellosis
129 Pertussis and Other Bordetella Infections
130 Donovanosis (Granuloma inguinale)
131 Campylobacter Species
132 Tularemia
133 Haemophilus influenzae
134 Other Haemophilus Species (ducreyi, haemolyticus, influenzae biogroup aegyptius, and parainfluenzae)
135 Helicobacter pylori
136 Kingella kingae
137 Legionnaires’ Disease, Pontiac Fever, and Related Illnesses
138 Q Fever
139 Streptobacillus moniliformis (Rat-Bite Fever)
140 Bartonella Infections
SUBSECTION VI Treponemataceae
141 Lyme Disease
142 Relapsing Fever
143 Leptospirosis
144 Spirillum minus (Rat-Bite Fever)
145 Syphilis
146 Nonvenereal Treponematoses
SUBSECTION VII Anaerobic Bacteria
147 Clostridial Intoxication and Infection
148 Infant Botulism
149 Tetanus
150 Actinomycosis
151 Bacteroides, Fusobacterium, Prevotella, and Porphyromonas
VOLUME TWO
SECTION 17 Viral Infections
SUBSECTION I DNA—Parvoviridae
152 Human Parvovirus B19
153 Human Bocaviruses
SUBSECTION II DNA—Polyomaviridae
154 Human Polyomaviruses
155 Human Papillomaviruses
SUBSECTION III DNA—Adenoviridae
156 Adenoviruses
SUBSECTION IV DNA—Hepatoviridae
157 Hepatitis B and D Viruses
SUBSECTION V DNA—Herpesviridae
158 Herpes Simplex Viruses 1 and 2
159 Cytomegalovirus
160 Epstein-Barr Virus
161 Human Herpesviruses 6A, 6B, 7, and 8
162 Varicella Zoster Virus
SUBSECTION VI DNA—Poxviridae
163 Smallpox (Variola Virus)
164 Monkeypox and Other Poxviruses
165 Mimiviruses
SUBSECTION I RNA—Picornaviridae
166 Enteroviruses, Parechoviruses, and Saffold Viruses
167 Rhinoviruses
168 Hepatitis A Virus
SUBSECTION II RNA—Caliciviridae
169 Caliciviruses
170 Hepatitis E Virus
SUBSECTION III RNA—Reoviridae
171 Reoviruses
172 Orbiviruses, Coltiviruses, and Seadornaviruses: Colorado Tick Fever, Banna Virus, and Others
173 Rotavirus
SUBSECTION IV RNA—Togaviridae
174 Rubella Virus
175 Eastern Equine Encephalitis
176 Western Equine Encephalitis
177 Venezuelan Equine Encephalitis
178 Chikungunya
179 Ross River Virus Arthritis
180 Other Alphaviral Infections
SUBSECTION V Flaviviridae
181 St. Louis Encephalitis
182 West Nile Virus
183 Yellow Fever
184 Dengue, Dengue Hemorrhagic Fever, and Severe Dengue
185 Japanese Encephalitis
186 Murray Valley Encephalitis
187 Tick-Borne Encephalitis
188 Zika Virus Infections
189 Other Less Commonly Recognized Flaviviruses
190 Hepatitis C Virus
SUBSECTION VI Orthomyxoviridae
191 Influenza Viruses
SUBSECTION VII Paramyxoviridae
192 Parainfluenza Viruses
193 Measles Virus
194 Mumps Virus
195 Respiratory Syncytial Virus
196 Human Metapneumovirus
SUBSECTION VIII Rhabdoviridae
197 Rabies Virus
SUBSECTION IX Arenaviridae and Filoviridae
198 Lymphocytic Choriomeningitis Virus
199 Arenaviral Hemorrhagic Fevers
200 Filoviral Hemorrhagic Fever: Marburg and Ebola Virus Fevers
SUBSECTION X Coronaviridae and Torovirdae
201 Human Coronaviruses
SUBSECTION XI Bunyaviridae
202 Hantaviruses
203 La Crosse Virus and Other California Serogroup Viruses
204 Rift Valley Fever
205 Crimean-Congo Hemorrhagic Fever
206 Phlebotomus Fever (Sandfly Fever),
207 Oropouche Fever
208 Toscana Virus
SUBSECTION XII Retroviridae
209 Oncoviruses (Human T-Cell Lymphotropic Viruses) and Lentiviruses (Human Immunodeficiency Virus Type 2)
210 Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
SUBSECTION XIII Prion-Related Diseases
211 Transmissible Spongiform Encephalopathies (Creutzfeldt-Jakob Disease, Gerstmann-Sträussler-Scheinker Disease, Kuru, Fatal Familial Insomnia, New Variant Creutzfeldt-Jakob Disease, Sporadic Fatal Insomnia, Variably Protease Sensitive Prionopathy)
SECTION 18 Chlamydia
212 Chlamydia Infections
SECTION 19 Rickettsial Diseases
213 Rickettsial and Ehrlichial Diseases
SECTION 20 Mycoplasma
214 Mycoplasma and Ureaplasma Infections
SECTION 21 Fungal Diseases
215 Aspergillosis
216 Blastomycosis
217 Candidiasis
218 Coccidioidomycosis
219 Paracoccidioidomycosis
220 Cryptococcosis
221 Histoplasmosis
222 Sporotrichosis
223 Mucormycosis and Entomophthoramycosis
224 Fusariosis and Scedosporiosis
225 Miscellaneous Mycoses
SECTION 22 Parasitic Diseases
SUBSECTION I Protozoa
226 Amebiasis
227 Blastocystis hominis and Blastocystis spp. Infection
228 Entamoeba coli Infection
229 Giardiasis
230 Dientamoeba fragilis Infections
231 Trichomonas Infections
232 Balantidium coli Infection
233 Cryptosporidiosis
234 Cyclosporiasis, Cystoisosporiasis, and Microsporidiosis
235 Babesiosis
236 Malaria
237 Leishmaniasis
238 Trypanosomiasis
239 Naegleria, Acanthamoeba, and Balamuthia Infections
240 Toxoplasmosis
241 Pneumocystis Pneumonia
SUBSECTION II Nematodes
242 Parasitic Nematode Infections
SUBSECTION III Cestodes
243 Cestodes
SUBSECTION IV Trematodes
244 Foodborne Trematodes
245 Schistosomiasis
SUBSECTION V Arthropods
246 Arthropods
SECTION 23 Global Health
247 Global Health
248 International Travel Considerations for Children
249 Infectious Disease Considerations in International Adoptees and Refugees
PART IV Therapeutics
250 Antibiotic Resistance
251 The Pharmacokinetic-Pharmacodynamic Interface: Determinants of Antiinfective Drug Action and Efficacy in Pediatrics
252 Antibacterial Therapeutic Agents
253 Antimicrobial Prophylaxis
254 Outpatient Intravenous Antimicrobial Therapy for Serious Infections
255 Antiviral Agents
256 Antifungal Agents
257 Drugs for Parasitic Infections
258 Immunomodulating Agents
259 Probiotics
PART V Prevention of Infectious Diseases
260 Health Care–Associated Infections
261 Antimicrobial Stewardship
262 Active Immunizing Agents
263 Passive Immunization
SECTION 24 Other Preventive Considerations
264 Public Health Aspects of Infectious Disease Control
265 Infections in Out-of-Home Childcare
266 Animal and Human Bites
267 Bioterrorism
PART VI Approach to the Laboratory Diagnosis of Infectious Diseases
268 Bacterial Laboratory Diagnosis
269 Fungal Diagnostics for Pediatric Patients
270 Viral Laboratory Diagnosis
271 Parasitic Laboratory Diagnosis
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